美國PeproTech公司是全球最大的重組細胞因子和蛋白生產(chǎn)商之一，始終致力于為生命科學(xué)研究開發(fā)重組蛋白及相關(guān)產(chǎn)品，如今已成為能提供多種高質(zhì)量細胞因子和重組蛋白，相應(yīng)的單克隆、多克隆和生物素標記抗體，以及ELISA試劑盒的世界領(lǐng)導(dǎo)者。PeproTech.的產(chǎn)品涵蓋免疫調(diào)節(jié)蛋白、白介素、集落刺激因子、生長因子、無動物成分的重組蛋白、化學(xué)趨化因子、干擾素、脂聯(lián)素、成纖維生長因子、轉(zhuǎn)化生長因子、腫瘤壞死因子、神經(jīng)營養(yǎng)素和防御素等諸多生命科學(xué)研究領(lǐng)域中重要的生物活性分子。PeproTech公司的產(chǎn)品種類、規(guī)格齊全，更新速度快，且價格適中，已廣為中國的科研工作者所使用。

為跟蹤當今科研發(fā)展、滿足日益增長的需求，PeproTech公司追求不斷創(chuàng)新和與時俱進。PeproTech公司2015年11月推出3種新產(chǎn)品，分別是：

1. 重組人FGFR3a(IIIc) Fc
產(chǎn)品描述：The FGF family plays a central role during prenatal development and postnatal growth, and the regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. The FGF ligands bind to a family of type I transmembrane tyrosine kinase receptors, which leads to dimerization and activation by sequential autophosphorylation of specific tyrosine residues. Four genes encoding structurally related FGF receptors (FGFR-1 to -4) are known. Alternative splicing of the mRNAs generates numerous forms of FGFR-1 to -3. Alternate forms of FGF receptors can exhibit different specificities with respect to ligand binding. For example, the form designated as FGFR1a (IIc) interacts predominantly with FGF-acidic (FGF1) and FGF-basic (FGF2). A frequent splicing event involving FGFR-1 and -2 results in receptors containing all three Ig domains, referred to as the alpha isoform, or only IgII and IgIII, referred to as the beta isoform. Only the alpha isoform has been identified for FGFR-3 and FGFR-4. Additional splicing events for FGFR-1 to -3, involving the C-terminal half of the IgIII domain encoded by two mutually exclusive alternative exons, generate FGF receptors with alternative IgIII domains (IIIb and IIIc). PeproTech’s CHO cell-derived Recombinant Human FGFR3 (IIIc) Fc is a glycosylated, disulfide-linked homodimer of 1,170 amino acid residues whose monomer consists of the 353-amino-acid length extracellular portion of FGFR3a (IIc) fused to the 231-amino-acid length Fc portion of human IgG1 by a single glycine. The calculated molecular weight ofCHO cell-derived Recombinant Human FGFR3 (IIIc) Fc is 128.3 kDa, however, it migrates at an apparent molecular weight of approximately 100-110 kDa by SDS-PAGE analysis under reducing conditions due to glycosylation.

2. 重組人Leptin
產(chǎn)品描述：Encoded by the ob (obese) gene, Leptin is an adipose-derived cytokine that suppresses appetite and increases thermogenesis. Leptin exerts its anorectic effect via signaling through a hypothalamic receptor termed OB-R. Leptin has been shown to reduce body weight, food consumption, and plasma glucose levels in various in vivo models. Recombinant Human Leptin is a 16.0 kDa protein containing 147 amino acid residues. Manufactured using all Animal-Free reagents.

3. 重組小鼠Leptin
產(chǎn)品描述：Encoded by the ob (obese) gene, Leptin is an adipose-derived cytokine that suppresses appetite and increases thermogenesis. Leptin exerts its anorectic effect via signaling through a hypothalamic receptor termed OB-R. Leptin has been shown to reduce body weight, food consumption, and plasma glucose levels in various in vivo models. Recombinant Murine Leptin is a 16.2 kDa protein containing 147 amino acid residues. Manufactured using all Animal-Free reagents.


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