動物術(shù)中和術(shù)后保溫是動物實驗過程中的一個至關(guān)重要的環(huán)節(jié)，是否做好保溫措施直接關(guān)系到實驗的成敗，同時也是科研工作者在進行生命科學相關(guān)研究中將實驗動物倫理和福利付諸實踐的真正體現(xiàn)，是對動物愛心的社會責任感的體現(xiàn)。善待活著的動物，減少動物死亡的痛苦�。。�

動物手術(shù)保溫的科學價值

Responsible scientists know that good science and good animal care go hand in hand, and would not tolerate cruel or inhumane treatment of any laboratory animal.

------The U.S. Animal Welfare Act

美國動物福利法案申明指出“負責的科學家深知，好科學與善待動物是相輔相成的，我們不能容忍殘殺或不人道的對待任何實驗動物�！�

保障動物實驗結(jié)果準確性：科研效果更好、結(jié)果可信、更加客觀真實

動物手術(shù)低體溫的危害

為什么需要對手術(shù)動物進行保溫？

1. 損害機體免疫功能，減少皮膚血流和氧供，增加傷口感染率

2. 降低血流循環(huán)和血液指標，導致凝血發(fā)生，非常不利于血液或血流相關(guān)指標監(jiān)測和測定，比如測量血流量、血壓等

3. 降低藥物在機體組織中的代謝速度，影響機體代謝

4. 延長麻醉恢復時間，可能明顯增加動物死亡率

5. 引起其他疾病的發(fā)生，比如心血管并發(fā)癥

6. 無法得到真實或接近真實的實驗數(shù)據(jù)

7. More………

動物手術(shù)低體溫的常見原因

• 1.麻醉劑的作用：麻醉劑導致擴張血管、抑制體溫調(diào)節(jié)，從而導致體溫下降

• 2.手術(shù)室的低溫環(huán)境，尤其是普通動物室實驗環(huán)境

• 3.手術(shù)臺的“冷”材質(zhì)，比如不銹鋼、樹脂材質(zhì)的臺面

• 4.長時間藥物注射：長時間輸入與環(huán)境等溫的液體，對動物體液造成“冷稀釋”作用，從而導致動物體溫下降

• 5.皮膚消毒劑的使用，尤其是裸露皮膚大面積的消毒，導致體內(nèi)熱量散失

• 長時間的手術(shù)

• 6.創(chuàng)傷較大的開胸、開腹手術(shù)，造成熱量散發(fā)較多

• 7.動物自身年齡、疾病因素，如營養(yǎng)不良、腫瘤模型手術(shù)

• Others………

動物手術(shù)保溫的常見措施

Solution 1

Solution 2

動物手術(shù)保溫的規(guī)范操作

術(shù)中

1.如果使用電熱毯保溫方式，切忌電熱毯直接放置于不銹鋼、樹脂等“冷”材質(zhì)手術(shù)臺面，因這些材質(zhì)傳熱會導致電熱毯加熱很慢甚至無法升溫到預期溫度；
2.除手術(shù)部位外，其他部位盡量不暴露，可以使用布巾遮蓋；
3.如果是注射液體或藥物，且實驗時間較長，必要時，可以同時對輸進動物體內(nèi)的液體進行預熱；
4.手術(shù)操作配合熟練，減少手術(shù)時間；
5.注意體溫監(jiān)測。

術(shù)后

• 繼續(xù)將動物放于保溫毯或保溫臺上，待動物恢復。

動物手術(shù)麻醉、保溫全套方案

Solution 1

此套方案集吸入麻醉、立體定位和動物手術(shù)保溫全套功能于一體，是從事小鼠、大鼠等小動物神經(jīng)科學相關(guān)研究的標準配置，主要應(yīng)用范圍：

1. 1.光遺傳

2. 2.神經(jīng)電生理

3. 3.鈣成像

4. 4.微透析

5. 5.顱腦&脊髓損傷

6. 6.顱內(nèi)給藥

7. and more……..

Solution 2

此套方案集吸入麻醉、動物身體固定和手術(shù)保溫全套功能于一體，是從事小鼠、大鼠等小動物常用實驗的標準配置，主要應(yīng)用范圍：

1. 1.動物解剖、分離

2. 2.腦梗、心梗等模型造模

3. 3.心臟、尾靜脈、靜脈等缺血

4. 4.頸內(nèi)靜脈和尾靜脈給藥

5. 5.動物活體成像

6. and more……..

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