samp8快速老化小鼠、samr1小鼠部分用戶：寧夏醫(yī)科大學(xué)、中國中醫(yī)科學(xué)院、同濟醫(yī)院、中科院遺傳與發(fā)育研究所、北京師范大學(xué)、國家體育總局體育科學(xué)研究所、河北醫(yī)科大學(xué)，中國醫(yī)科大學(xué)、山東大學(xué)、齊魯醫(yī)院、復(fù)旦大學(xué)、瑞金醫(yī)院、中科院上海藥物研究所、上海交通大學(xué)、第二軍醫(yī)大學(xué)、第四軍醫(yī)大學(xué)、中科院生物物理所、南方醫(yī)科大學(xué)、武漢協(xié)和、中國醫(yī)學(xué)科學(xué)院等均使用本單位提供動物進行研究

有各月齡SPF級SAMP8小鼠samp8mice快速老化小鼠銷售價格優(yōu)惠，SPF級SAMR1小鼠samp8mice快速老化小鼠銷售價格優(yōu)惠，保質(zhì)保量，提供質(zhì)量合格證，可送貨到實驗室

STRAIN NAME: Senescence accelerated mouse/prone8
TYPE: Spontaneous mutation
BACKGROUND STRAIN: AKR/J
COAT COLOR: White (Albino)
ORIGIN: In 1968, the United States (Bar Harber ME) Jackson laboratory presented to a few of the AKR / J mice the in Kyoto, Japan (Kyoto) University,.in Feeding and breeding process, Takeda found several mice showed different degrees epilation, rough skin, cataracts, behavioral disorders and shortened survival phenomena and have a genetic predisposition. In 1975, they carefully selected the five nest obvious aging AKR / J mice as the P series ancestors, normal aging process of mice as the R line ancestor. Select the P series, R series main criteria for degree of aging (in 8 mon degree of aging), survival period and pathological changes based on diseases associated with aging. According to the survival curve (Gompertzian function) and degree of aging get P series mice as rapid aging [1]. Therefore, P series called senescence accelerated mouse (Senescence accelerated mouse / prone, SAMP), R series known as the anti-senescence accelerated mouse.
Biology: SAMP 8 brain have a large number of Aβ deposition in the aging process. Northern hybridization analysis showed that, β-amyloid precursor protein (APP) mRNA expression did not change significantly. SAMP 8 occurred learning, memory dysfunction and Neurotransmitter change in the brain during the aging, such as the cerebral cortex and hippocampus of acetylcholine (Ach), norepinephrine (NE), dopamine (DA) and opioid peptides reduce, γ-aminobutyric acid (GABA) increased, 5 - hydroxytryptamine (5-HT) showed first increased and then decreased and so on. SAMP 8 at 2 mon occurs immune dysfunction ,the sheep red blood cells (SRBC)-induced spleen cell antibody response, Con A-induced lymphocyte proliferation and IL-2 production capacity decreased significantly. Further study found that SAMP8 CD+4 cells decreased and function decline in the spleen, NK cells normal. NK cell activity was significantly enhanced After using immunostimulants, NK cell activity decreased possible relate with IL-2 levels decline.
RESEARCH APPLICATION: learning and memory dysfunction, Evaluation of anti-aging and improve learning and memory drugs

至善健康醫(yī)學(xué)研究院成立于2005年，專業(yè)從事胚胎干細胞、分子生物醫(yī)學(xué)及基因工程動物模型敲除的技術(shù)研發(fā)、大鼠小鼠Morris水迷宮實驗外包服務(wù)及大鼠小鼠海馬側(cè)腦室aav病毒立體定位注射動物實驗服務(wù)，視網(wǎng)膜玻璃體定位注射實驗服務(wù)，分子生物醫(yī)學(xué)科研動物病理生理實驗外包動物病理醫(yī)學(xué)科研實驗外包技術(shù)服務(wù)，提供老年老齡sd大鼠及c57老年小鼠，設(shè)有干細胞生物學(xué)、分子生物學(xué)和基因工程動物表型分析實驗室，可提供用于科學(xué)研究和藥物研發(fā)的各類動物胚胎干細胞和人胚胎干細胞、成體細胞、基因工程干細胞株、臍帶間充質(zhì)干細胞、SD大鼠骨髓間充質(zhì)干細胞、小鼠骨髓間充質(zhì)干細胞及相關(guān)培養(yǎng)基，同時提供基因敲除小鼠訂購、轉(zhuǎn)基因小鼠訂購、基因沉默小鼠和轉(zhuǎn)基因小鼠等基因工程動物模型的構(gòu)建和基于干細胞的藥物研發(fā)服務(wù)。

    隨業(yè)務(wù)范圍的擴大，公司面向海內(nèi)外征集細胞生物學(xué)與分子生物學(xué)相關(guān)產(chǎn)品的合作伙伴。 經(jīng)營范圍：基因敲除小鼠模型建立、銷售基因敲除小鼠、銷售轉(zhuǎn)基因小鼠、顯微注射、基因打靶、條件性敲除、定點敲除轉(zhuǎn)基因載體、基因沉默（siRNA）和質(zhì)粒DNA表達載體構(gòu)建實驗技術(shù)服務(wù)；胚胎干細胞培養(yǎng)和細胞生物學(xué)實驗服務(wù)；基因敲除小鼠、基因沉默小鼠和轉(zhuǎn)基因小鼠構(gòu)建；各種細胞株（人胚胎干細胞、小鼠胚胎干細胞、iPS細胞、成體干細胞和腫瘤細胞）；細胞培養(yǎng)基；質(zhì)粒載體；超純水、雙蒸水、去離子水、醫(yī)用蒸餾水銷售小鼠基因敲除小鼠服務(wù)價格，RNA干擾載體構(gòu)建技術(shù)服務(wù)，人胚胎干細胞、小鼠胚胎干細胞培養(yǎng)技術(shù)服務(wù)，基因沉默小鼠構(gòu)建技術(shù)服務(wù)，siRNA載體構(gòu)建技術(shù)服務(wù)，基因沉默構(gòu)建技術(shù)服務(wù)，載體構(gòu)建技術(shù)服務(wù)，RNAi表達載體構(gòu)建服務(wù)，轉(zhuǎn)基因小鼠構(gòu)建，細胞生物學(xué)技術(shù)服務(wù)，分子生物學(xué)技術(shù)服務(wù)， pcDNA載體構(gòu)建實驗服務(wù)，siRNA質(zhì)粒載體構(gòu)建服務(wù)，細胞轉(zhuǎn)染技術(shù)服務(wù)。                    

      經(jīng)營范圍：出售銷售小鼠骨髓間充質(zhì)干細胞、出售銷售大鼠骨髓間充質(zhì)干細胞，出售銷售臍帶間充質(zhì)干細胞，基因敲除載體、轉(zhuǎn)基因載體、基因沉默（siRNA）和質(zhì)粒DNA表達載體構(gòu)建實驗技術(shù)服務(wù)；胚胎干細胞培養(yǎng)和細胞生物學(xué)實驗服務(wù)；基因敲除小鼠、基因沉默小鼠和轉(zhuǎn)基因小鼠構(gòu)建；各種細胞株（人胚胎干細胞、小鼠胚胎干細胞、iPS細胞、成體干細胞和腫瘤細胞）；細胞培養(yǎng)基；質(zhì)粒載體；基因敲除載體、轉(zhuǎn)基因載體、基因沉默載體構(gòu)建小鼠、siRNA質(zhì)粒載體構(gòu)建、RNA載體構(gòu)建實驗技術(shù)服務(wù)、RNAi載體構(gòu)建實驗技術(shù)服務(wù)、DNA表達載體構(gòu)建實驗技術(shù)服務(wù)；胚胎干細胞培養(yǎng)和細胞生物學(xué)實驗服務(wù)；基因敲除小鼠、基因沉默小鼠和轉(zhuǎn)基因小鼠構(gòu)建；   

      公司秉承“科學(xué)至上，銳意進取”的經(jīng)營理念，堅持“客戶第一”的原則為廣大客戶提供優(yōu)質(zhì)的服務(wù)。歡迎惠顧！